Critical Limb Ischaemia


Critical Limb Ischaemia (CLI) (or called Peripheral arterial disease) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue and other substances in the blood. Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.

Peripheral arterial disease (PAD), causing an inadequate oxygen supply to the limbs. Mainly the risk factors of peripheral vascular disease are nicotine use, diabetes mellitus, hypertension and hypercholesterolemia. Based on the severity of the symptoms, usually two clinical presentations are distinguished: Intermittent claudication (IC) is characterized by pain upon walking which is the most common presenting symptom “Critical limb ischemia (CLI)” is a more severe form in which pain occurs at rest and which is accompanied by necrosis and ulceration and patients with CLI are also at high risk for limb amputation.


Currently available surgical or endovascular revascularization treatment cannot be done in those patients who could not have arterial bypass graft surgery due to poor run-off or poor general medical condition. There may be some side effect by using the conventional method for peripheral arterial disease.

Bone Marrow derived Stem cells transplantation via intra-muscular and intra-arterial (via using with balloon catheter) provide neoangiogenesis (new vessel formation) in ischemic tissue. It is the only most effective treatment option for Critical Limb Ischaemia patients (severe peripheral arterial disease) and to reduce the major amputation. For obtaining a high local stem cell concentration in the ischemic leg, we use a new route of transplantation by combining both intra-arterial (by using with balloon catheter) and intra-muscular injections so that high concentration of stem cells can reach into all ischemic muscles. Bone Marrow Mononuclear cells (BM-MNC or BM stem cells concentrate) is more useful in peripheral arterial disease to get more re-vascularization because it contains all needed regenerative cells and the hematopoietic stem cells (HSCs) in the BM-MNC release angiogenic growth factors such as vascular endothelial growth factor (VEGF) which improves endothelium-dependent vasodilation in patients with peripheral arterial disease. Autologous BM-MNC implantation improves ankle-brachial index (ABI) measurements, SaO2 relief of rest pain, and ulcer healing and also to reduce major amputations. Otherwise patients require 1-2 tabloids to achieve good stem cell dose in our body because stem cell supplement work similar to stem cell therapy.

Stem Cell Treatment which can be given via multiple injection in the selective hospitals/clinics at very huge cost (10,000-25,000 USD) but stem cell supplement which can be shipped in secure packages and delivered right to your home at very affordable price than stem cell transplantation.



Basically we have two types of stem cell supplements which work equally as stem cell therapy. Get more detail on our all two types of stem cell supplement in detail:-

1 – Sheep Placenta derived Tabloids: – Placenta derived stem cell supplement which has been made first time in Switzerland and manufactured under the FDA approved and cGMP registered Pharmaceutical Facility here in the United States which obtains trust with maximum quality, safety and consistency. This is the only Stem Cell Supplement product in world which is made by sheep stem cells (tabloid form) through Dry Freezing Technology (patented method). Sheep placenta tabloid delivers stem cells at good amount which remain biologically active (using a proven technique for gently conserving biological substances) without damaging the effectiveness of their valuable bioactive matter and it can be shipped in secure packages and delivered right to your home. Being enteric coated this softgel tabloids dissolve in the small intestine whereby the stem cells and other active ingredients are fully absorbed by the body. To get better results and benefits of this supplement, we prescribe to take 1 – 3 softgel tabloids in one day.

2 – Stem Cell Worx: – Another supplement “Stem Cell Worx” (Intaoral spray) is natural dietary health supplement which contain some natural ingredient (Bovine Colostrum, Trans Resveratrol & Fucoidan) which is helpful to increase the circulation of stem cells in the body for an extended period of time and help to make your body healthy and disease free for a long time. This supplement activates your own adult stem cells naturally and provides robust immunity and stimulates your body’s natural repair system.

Our Objective:-
1. To improve revascularization in atherosclerotic artery
2. Increase pain free walking time
3. Reduce the risk of amputation rates
4. Improve the Ulcer/Gangrene healing


Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor resting ankle-brachial pressure index (ABI), arterial oxygen saturation (SaO2), pain-free walking time and rest pain scale evaluation.


1. T. Bartsch et al. 2007 (Clinical Research in Cardiology). Transplantation of Autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (TAM-PAD study).

2. Hernandez et al. 2007 (Atherosclerosis). Autologous bone-marrow mononuclear cell implantation in patients with severe lower limb ischaemia: A comparison of using blood cell separator and Ficoll density gradient
If you have further any queries related to stem cell supplement for “Critical Limb Ischemia” then contact us without any hesitation on our contact numbers:- +91-9650-988899/699988