WHAT IS KIDNEY
Kidneys are a pair of bean-shaped organs that lie in abdominal cavity. It is essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and regulation of blood pressure (via maintaining salt and water balance). They serve the body as a natural filter of the blood, and remove wastes which are diverted to the urinary bladder. In producing urine, the kidneys excrete wastes such as urea and ammonium.
CHRONIC KIDNEY DISEASE
Chronic kidney disease occurs when one suffers from gradual and usually permanent loss of kidney function over time. With loss of kidney function, there is an accumulation of water; waste; and toxic substances, in the body, that are normally excreted by the kidney. Loss of kidney function also causes other problems such as anemia, high blood pressure, acidosis (excessive acidity of body fluids). Although the major causes of chronic kidney disease are diabetes and hypertension. The stage-5 patient is called end stage or chronic kidney disease patient.
Table 1. Stages of Chronic Kidney Disease
|1.||Slight kidney damage with normal or increased filtration||More than 90|
|2.||Mild decrease in kidney function||60-89|
|3.||Moderate decrease in kidney function||30-59|
|4.||Severe decrease in kidney function||15-29|
|5.||Kidney failure||Less than 15 (or dialysis)|
*GFR is glomerular filtration rate, a measure of the kidney’s function
STEM CELL SUPPLEMENT/THERAPY FOR CHRONIC KIDNEY DISEASE (CKD)
The kidney is a highly complex organ, composed of more than 30 different cell types in different compartments, such as tubular epithelial cells, interstitial cells, glomerular cells and cells of the vasculature. Currently the CKD patients are increasing worldwide and there is no appropriate treatment available for chronic kidney disease. So based on successful experiment on the animals & humans, now researchers are hopeful of its application on human being.
Chronic kidney disease causes dysfunction of the cells from vascular, interstitial, glomerular and tubular compartments which triggers the release of fibrogenic cytokines and recruitment of inflammatory cells to injured kidneys. The rapid interposition of scar tissue probably confers a survival advantage by preventing infectious microorganisms from invading the wound, but prevents subsequent tissue or renal cell regeneration.
Stem cell transplantation into CKD patient may provide improvement like reduced creatinine level because stem cells like mesenchymal stem cell has the property to differentiate into renal specific cells such as nephron, tubular epithelial cells, nephron and others. After infusion of stem cells into the CKD patients via using catheterization into the renal artery, then start to regenerate the damaged/injured renal tissue and also induce/activate resident stem cells in the renal via para/autocrine signaling. Stem cells therapy provides better environment to regenerate the damaged cells via differentiating into the renal specific cells and also induce the resident stem cells. Otherwise patients require 1-2 tabloids to achieve good stem cell dose in our body because stem cell supplement work similar to stem cell therapy.
Stem Cell Treatment which can be given via multiple injection in the selective hospitals/clinics at very huge cost (10,000-25,000 USD) but stem cell supplement which can be shipped in secure packages and delivered right to your home at very affordable price than stem cell transplantation.
STEM CELL SUPPLEMENT:-
Basically we have two types of stem cell supplements which work equally as stem cell therapy. Get more detail on our all two types of stem cell supplement in detail:-
1 – Sheep Placenta derived Tabloids: – Placenta derived stem cell supplement which has been made first time in Switzerland and manufactured under the FDA approved and cGMP registered Pharmaceutical Facility here in the United States which obtains trust with maximum quality, safety and consistency. This is the only Stem Cell Supplement product in world which is made by sheep stem cells (tabloid form) through Dry Freezing Technology (patented method). Sheep placenta tabloid delivers stem cells at good amount which remain biologically active (using a proven technique for gently conserving biological substances) without damaging the effectiveness of their valuable bioactive matter and it can be shipped in secure packages and delivered right to your home. Being enteric coated this softgel tabloids dissolve in the small intestine whereby the stem cells and other active ingredients are fully absorbed by the body. To get better results and benefits of this supplement, we prescribe to take 1 – 3 softgel tabloids in one day.
2 – Stem Cell Worx: – Another supplement “Stem Cell Worx” (Intaoral spray) is natural dietary health supplement which contain some natural ingredient (Bovine Colostrum, Trans Resveratrol & Fucoidan) which is helpful to increase the circulation of stem cells in the body for an extended period of time and help to make your body healthy and disease free for a long time. This supplement activates your own adult stem cells naturally and provides robust immunity and stimulates your body’s natural repair system.
Advantages of stem cell supplement after transplantation
• Immune modulation
• Anti inflammatory
• Anti- fibrosis
Stem cell may reduce/maintain serum creatinine level in end stage/chronic kidney patient for a long time but there is no assurance that it may be alternative of kidney transplant in future after stem cell therapy. As kidney transplant success rate is not 100% in kidney failure patient and some patient may get again kidney related problem even after kidney transplant because of the usage of immunosuppressant drug for a long time so if patients who already got kidney transplant and again facing kidney disease then such type of patients also may get stem cell therapy because It may reduce/maintain serum creatinine level and also reduce the immunosuppressant drug dosage because mesenchymal stem cell has the immune-modulation property and suppress the activation of T-regulatory cells after infusion.
1. Sen et al. 2012. JAMA. Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants
If you have further any queries related to stem cell supplement/therapy for “Kidney Failure” then contact us without any hesitation on our contact numbers:- +91-9650-988899/699988