Liver disease is any condition that causes liver inflammation or tissue damage and affects liver function. The liver is a vital organ located in the upper right-hand side of the abdomen. It is as large as a football, weighs 2-3 pounds, and performs numerous functions for the body: converting nutrients derived from food into essential blood components, storing vitamins and minerals, regulating bloods clotting, producing proteins and enzymes, maintaining hormone balances, and metabolizing and detoxifying substances that would otherwise be harmful to the body. The liver makes factors that help the human immune system fight infection, removes bacteria from the blood, and makes bile, which is essential for digestion.
WHAT IS LIVER DISEASE
Liver disease is categorized both by the cause and the effect it has on the liver. Causes may include infection, injury, exposure to drugs or toxic compounds, an autoimmune process or a genetic defect that leads to the deposition and build-up of damaging substances such as iron or copper. Effects may include inflammation, scarring, obstructions, clotting abnormalities, and liver failure.
OTHER TREATMENTS FOR LIVER DISEASE
Although liver has a very good regenerative capacity but in chronic liver damage, this begins to fail, and then fibrosis, and eventually cirrhosis develops, called end stage liver disease (ESLD). Chronic liver disease is the fifth leading cause of death after cancer, cardiovascular disease, stroke, and respiratory disease.
At present liver transplantation is the only therapeutic option for patients with acute and chronic ESLDs and liver based metabolic defects. Liver transplantation, however, has the disadvantage of requiring lifelong immunosuppressant with 10–15% of patients dying whilst on the waiting list due to the shortage of donated organs.
Previously hepatocyte Cells transplantation has been suggested as an alternative to liver transplantation, especially for hepatic disorders but the widespread application of hepatocyte transplantation, however, is also limited by organ availability, by problems with viability of isolated hepatocytes after cryopreservation, and by the potential formation of hepatocyte aggregates after transplantation because hepatocyte cell has the problems of insufficient cell survival and engraftment.
STEM CELL THERAPY FOR LIVER DISEASE
A lot of clinical trials have shown that Stem cell therapy is successful in liver related disorder like acute liver failure or end stage liver disease (ESLDs). So the concept is that stem cell has the potential to diffrentiated into hepatocyte cells after transplantation in liver disease and show improvement for all the evaluations in liver related disorder.
STEM CELL SUPPLEMENT/TRANSPLANTATION FOR LIVER DISEASE
Stem Cell therapy offers the potential benefits when transplanted into liver disease.
1. Stem cell can differentiate or regenerate into hepatocyte cells so recover the damaged hepatocytes cells in the liver cirrhosis.
2. Stem cell transplant also provide new vascularization so it provides good environment for the renewal, differentiation of stem cells into hepatocytes.
3. Stem cell provides immune-regulatory properties by secreting anti-inflammatory cytokines so stop inflammation and slow down or stop further deterioration of hepatocytes cells.
As we know that stem cell supplement work similar to stem cell treatment so we require 1-2 tabloids to achieve good stem cell dose in our body. Stem Cell Treatment which can be given via multiple injection in the selective hospitals/clinics at very huge cost (10,000-25,000 USD) but stem cell supplement which can be shipped in secure packages and delivered right to your home at very affordable price than stem cell transplantation.
TABLE 1: CLINICAL TRIALS OF BONE MARROW STEM CELLS IN LIVER DISEASE.
|Reference||Patient group||Number (n)||Site injection||BM cells||Outcome|
|Am Esch et. al.||Patients with liver cancer, no cirrhosis||Study: 3 Control: 3||Portal vein||Autologous, bone marrow, CD133+||2.5-fold increase in left lobe in study group on CT volumetry|
|Gordon et al.||Hepatitis B or C Alcoholic cirrhosis and primary sclerosing cholangitis||5||Portal vein 3 Hepatic artery 2||Autologous peripheral blood, post-G-CSF CD34+||Improvement in albumin or bilirubin in 3/5 patients|
|Terai et al.||Hepatitis B or C Cirrhosis||9||Peripheral vein||Autologous, iliac crest, unsorted BM||Improve in the Child-Pugh Score and albumin|
|Yannaki et al.||Alcoholic cirrhosis||2||Peripheral vein||Autologous Peripheral blood, post-G-CSF CD34+||Improvement in the Child-Pugh and MELD Score|
|Furst et al.||Patients with liver cancer, no cirrhosis||Study: 6 Control: 7||Portal vein||Autologous, bone marrow, CD133+||Increase in daily liver growth|
|Lyra et al.||Alcoholic, hepatitis C, cholestatic and cryptogenic cirrhosis||10||Hepatic artery||Autologous, Iliac crest, unsorted BM||Improvement in Child’s Pugh score, bilirubin, and albumin|
|Gasbarrini et al.||Drug-induced acute liver failure||1||Portal vein||Autologous Peripheral blood, post-G-CSF CD34+||Autologous Peripheral blood, post-G-CSF CD34+|
|Yan et al.||Hepatitis B cirrhosis||2||Hepatic artery||Autologous peripheral blood monocytes post-G-CSF||Improve in albumin, Bilirubin, AST, ALT, and the Child-Pugh Score|
|Mohamadnejad et al.||Decompensated cirrhosis||4||Peripheral vein||Autologous bone marrow mesenchymal stem cells||MELD Score improvement in 2 patients|
|Pai et al.||Alcoholic liver cirrhosis||9||Hepatic artery||Autologous, post-G-CSF, CD34+cells expanded in vitro||Significant improvement in bilirubin and liver enzymes|
|Khan et al.||Hepatitis B or C||4||Hepatic artery||Autologous, post-G-CSF, CD34+cells||Improvement in liver function|
|Kharaziha et al.||Hepatitis B or C Alcoholic cirrhosis and Cryptogenic||8||Peripheral or portal vein||Autologous bone marrow mesenchymal stem cells||Significant improvement in MELD Score|
STEM CELL SUPPLEMENT:-
Basically we have two types of stem cell supplements which work equally as stem cell therapy. Get more detail on our all two types of stem cell supplement in detail:-
1 – Sheep Placenta derived Tabloids: – Placenta derived stem cell supplement which has been made first time in Switzerland and manufactured under the FDA approved and cGMP registered Pharmaceutical Facility here in the United States which obtains trust with maximum quality, safety and consistency. This is the only Stem Cell Supplement product in world which is made by sheep stem cells (tabloid form) through Dry Freezing Technology (patented method). Sheep placenta tabloid delivers stem cells at good amount which remain biologically active (using a proven technique for gently conserving biological substances) without damaging the effectiveness of their valuable bioactive matter and it can be shipped in secure packages and delivered right to your home. Being enteric coated this softgel tabloids dissolve in the small intestine whereby the stem cells and other active ingredients are fully absorbed by the body. To get better results and benefits of this supplement, we prescribe to take 1 – 3 softgel tabloids in one day.
2 – Stem Cell Worx: – Another supplement “Stem Cell Worx” (Intaoral spray) is natural dietary health supplement which contain some natural ingredient (Bovine Colostrum, Trans Resveratrol & Fucoidan) which is helpful to increase the circulation of stem cells in the body for an extended period of time and help to make your body healthy and disease free for a long time. This supplement activates your own adult stem cells naturally and provides robust immunity and stimulates your body’s natural repair system.
1. Salama et al. 2010 (Cell Transplant). Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases.
2. Khan et al. 2008 (Transplant Proc). Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a preliminary study.
If you have further any queries related to stem cell supplement/therapy for “Liver Disease” then contact us without any hesitation on our contact numbers:- +91-9650-988899/699988